Cholesterol: An Achilles' Heel for Glioblastoma?

In this issue of Cancer Cell, Villa et al. report that survival of glioblastoma cells is dependent on uptake of cholesterol. A synthetic agonist of the Liver X receptor depleted cholesterol in GBM cells, slowing growth of GBM xenografts.

Cancer cell. 2016 Nov 14 [Epub]

Zhenyi An, William A Weiss

Departments of Neurology, Pediatrics, and Neurosurgery, Brain Tumor Research Center, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Departments of Neurology, Pediatrics, and Neurosurgery, Brain Tumor Research Center, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: This email address is being protected from spambots. You need JavaScript enabled to view it..