Relationship Between Aldosterone Synthase CYP1A1 MspI Gene Polymorphism and Prostate Cancer Risk.

This study was conducted to assess the relationship between aldosterone synthase CYP1A1 MspI gene polymorphism and prostate cancer risk using meta-analysis.

The search was conducted in PubMed and China Biological Medicine Database disc on October 1, 2015, and eligible reports were recruited and synthesized using meta-analysis method.

The eligible reports were recruited into this meta-analysis for the association of CYP1A1 MspI gene polymorphism with prostate cancer risk. In this meta-analysis, CYP1A1 MspI TT genotype was associated with prostate cancer risk, but the association for C allele and CC genotype was not found in this meta-analysis (C allele: odds ratio = 1.11, 95% confidence interval: 0.96-1.29, P = .15; CC: odds ratio = 0.92, 95% confidence interval: 0.75-1.13, P = .43; TT: odds ratio = 0.80, 95% confidence interval: 0.66-0.97, P = .02).

CYP1A1 MspI TT genotype was associated with prostate cancer susceptibility. However, more studies should be conducted in the future to confirm them.

Technology in cancer research & treatment. 2016 Jan 13 [Epub ahead of print]

Chao Ou, Yan Zhao, Jiang-Hua Liu, Bo Zhu, Pei-Zhang Li, Hui-Liu Zhao

Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China., Center for Reproductive Medicine, Qingdao Women and Children Hospital, Qingdao, China., Department of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China., Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China., Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China This email address is being protected from spambots. You need JavaScript enabled to view it..